Objective To understand the sub-health status of students in 4 colleges and universities in Luzhou City，analyze its influencing factors，and provide a basis for formulating improvement measures. Methods Stratified sampling was conducted according to the proportion of the number of 4 colleges and universities in Luzhou City. The self-administered questionnaire survey was conducted using the SHMSV1.0 scale，and SPSS17.0 software was used for statistical analysis of the data. Results Among 2 115 respondents，the overall sub-health detection rate was 68.0%，and the sub-health detection rates of physiology，psychology and society were 66.4%，70.2% and 74.0% respectively. The analysis of influencing factors found that staying up late and conscious stress were the common influencing factors of all dimensions； the regularity of three meals could affect the overall，physical and psychological sub-health； the higher monthly disposable living expenses affected the overall (OR = 1.171)，psychological (OR = 0.830) and social(OR = 1.178) sub-health； the longer the use of mobile phones，the higher the detection rate of psychological (OR = 1.095) and social (OR = 1.098) sub-health. In addition，the influencing factor of overall sub-health was grade (OR =1.225)； physical sub-health was related to higher per capita monthly household income (OR = 1.076)； the detection rate of female mental sub-health (OR = 1.363) was higher than that of males； educational background (OR = 0.716) was an influencing factor of social sub-health. Conclusion The sub-health status of college students in Luzhou city is relatively serious. Female students，people with higher monthly disposable living expenses and higher conscious pressure are the key prevention and control groups. In addition，health education on staying up late，exercising and time management of mobile phone usage should be strengthened，which may be beneficial for improving the sub-health status of college students.