Objective:To design the biological zipper for the animal model of abdominal wall zipper of the miniature pig and test its biocompatibility.Methods:The shape of the biological zipper was designed in line with the size and living habits of the miniature pig

and the demands for animal surgery.According to the series standards of GB/T16886.10-2005

the skin irritation and the skin sensitization experiments were carried out on miniature pigs.Results:The constructed biological zipper was easy to operate

could save operation time and reduce wound infections

and it has successfully obtained the state intellectual property patent(patent number:200920207646.1).No irritation on the integral or damaged skin of miniature pig was observed.Sensitization effect on the skin of miniature pig was not found.Conclusion:The biological zipper with reasonable design and satisfactory biocompatibility lays a good foundation for the animal model of abdominal wall zipper of the miniature pig in teaching

research and clinical application.