Objective:To explore the effects of ovariectomy(OVX)and estrogen replace treatment on total cholesterol

LDL

HDL

triglycerides

serum leptin and resist levels.Methods:Female SD rats(12 weeks)were divided into three groups: control Sham

OVX and OVX treated with estrogen(OVX +E2)(n=7

each group).10 days post operating

rats had been treated with estradiol benzoate(0.2 mg ip per day)(OVX + E2)and vehicle(Sham and OVX rats)for 30 days respectively.Total cholesterol

LDL

HDL

triglycerides were analyzed by chemistry analyzer

and ELISA kits were employed to analyze serum leptin and resistin levels.Results:Body mass was increased by OVX and significantly decreased by estrogen treatment.Total cholesterol and LDL level were upregulated after OVX.Estrogen treatment increase triglyceride level

while decreased total cholesterol and LDL level of OVX rats.No affect was found in serum leptin and resistin level of OVX or estrogen treatment groups.Conclusion:OVX led to body mass increase and lipid metabolism disturbance.Treated with E2

the body mass of the ovariectomized rats were decreased and the disturbance of lipid metabolism was partially improved.OVX and estrogen replacement can not affect serum leptin and resistin levels.