Objective:To investigate the expressions of SEDL(X-linked spondyloepiphyseal dysplasiatarda

SEDL)gene and its encoded protein sedlin in a variety of tissues in mice.Methods:Real-Time PCR and Western Blot were used to detect the expression levels of the SEDL mRNA and sedlin protein in 9 tissues in mice

respectively.And the expression levels of them in bone tissues in mice of 1

2 and 4-week-old were also measured in the same way.Results:①Expressions of SEDL gene and its corresponding sedlin protein were existed in 9 tissues detected in mice.The relative expression levels of SEDL mRNA and sedlin protein in tissues in mice were significantly different (P<0.0001)

and with a high level in bone.②In bone tissues of age varied mice

the relative expression levels of SEDL gene and sedlin were obviously different(P<0.01)

and age-related changes in expressions were identical with each other.Conclusion:It was concluded that expressions of SEDL gene and sedlin were consistent in tested tissues.Expression levels of them were different among tissues and with a high level in bone.In bone tissues of mice

the expressions of SEDL gene and sedlin had the same changes with time.