Objective:To investigate the neuro protective effects of topiramate on the changes of the nerve function deficiency scores and the influence of it on the content of amino acids neurotransmitter of cerebral cortex of rats with cerebral ischemia.Methods:Male SD rats were subjected to right middle cerebral artery occlusion for 2h and reperfusied for 24 h.Rats in the treatment group were injected with topiramate suspl(8mg/ml

80mg/kg)at the begining of the artery occlusion and the reperfusion.The nerve function deficiency scores were measured.The infarct volume was evaluated through TTC staining.The content of amino acids of cerebral cortex was estimated by the method of high performance liquid chromatography(HPLC)with fluorescent detection.Results:The infarct volume was significantly reduced by 41.8% in the TPMtreated group compared with that in the control group.There were significant differences in the neurological impairment scores between the treatment group and the ischemia group.TPM significantly decreased the content of Glu(P<0.05)and increased the content of GABA(P<0.05).Conclusion:Topiramate maybe have some neuroprotective effect

which is probably related with its regulation on the relative equilibrium of Glu and GABA.