大鼠脑缺血再灌注损伤后NF-κB表达的研究

吴禹; 胡长林

doi:10.13406/j.cnki.cyxb.2008.03.019

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大鼠脑缺血再灌注损伤后NF-κB表达的研究

论著 | 更新时间：2024-01-17

- 大鼠脑缺血再灌注损伤后NF-κB表达的研究
- Study on the expression of nuclear factor-κB in ischemia-reperfusion rats
- 重庆医科大学学报 2008年第3期页码：329-330
- 作者机构：
  
  1. 重庆医科大学附属第二医院神经内科
  2. 重庆医科大学附属第二医院神经内科,重庆,400010
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2008.03.019
  中图分类号： R743
- 纸质出版日期：2008，
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[1]吴禹,胡长林.大鼠脑缺血再灌注损伤后NF-κB表达的研究[J].重庆医科大学学报,2008(03):329-330+340.

WU Yu. Study on the expression of nuclear factor-κB in ischemia-reperfusion rats[J]. Journal of Chongqing Medical University, 2008,(3):329-330.
[1]吴禹,胡长林.大鼠脑缺血再灌注损伤后NF-κB表达的研究[J].重庆医科大学学报,2008(03):329-330+340. DOI： 10.13406/j.cnki.cyxb.2008.03.019.

WU Yu. Study on the expression of nuclear factor-κB in ischemia-reperfusion rats[J]. Journal of Chongqing Medical University, 2008,(3):329-330. DOI： 10.13406/j.cnki.cyxb.2008.03.019.

摘要

目的:探讨NF-κB在大鼠脑缺血再灌注后炎性反应中的作用。方法:制备脑缺血再灌注模型。24h后

免疫组化检测假手术组、模型组和干预组中NF-κB p65的表达

测定脑组织匀浆中性粒细胞趋化因子（CINC）含量变化

同时观察海马CA1区病理组织学改变。结果:模型组大鼠脑组织的NF-κB p65阳性表达和CINC含量与假手术组相比明显增高

P<0.05;干预组大鼠脑组织的NF-κB p65阳性表达和CINC含量与模型组相比明显受抑制

P<0.05。干预组脑组织病理改变较模型组轻。结论:NF-κB参与了脑缺血再灌注后炎性反应中前炎性因子的调控过程。

Abstract

Objective:To investigate the role of nuclear factor-κB(NF-κB)in rats with cerebral ischemia-reperfusion injury. Methods:Rat models of cerebral ischemia-reperfusion were established.24hours later

the expression of NF-κB in rat brain of sham-operation group

operation group and intervention group was detected with immunohistochemistry method

Cytokin-induced neutrophil chemotactics(CINC)in rat brain were measured and histopathological examinations were conducted on the hippocampal CAl.Results:The expression of NF-κB p65 and CINC in the operation group increased significantly compared with the sham-operation group(P<0.05).But the expression of NF-κB p65 and CINC in the intervention group were inhibited significantly compared with the operation group(P<0.05).The pathological changes of the intervention group were slighter than those of the operation group.Conclusion:The results suggest that NF-κB may play an important role in the release of inflammation factors and gathering of inflammation cells induced by ischemia-reperfusion injury.

关键词

核转录因子-κB缺血再灌注大鼠

Keywords

nuclear factor-kappa Bischemia-reperfusionrat

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