乙型肝炎病毒携带产妇预防干预措施与母乳喂养的安全性研究

张建华; 王富兰; 胡燕; 胥飚; 邓安菊; 蒋丽

doi:10.13406/j.cnki.cyxb.2005.02.032

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乙型肝炎病毒携带产妇预防干预措施与母乳喂养的安全性研究

更新时间：2024-01-17

- 乙型肝炎病毒携带产妇预防干预措施与母乳喂养的安全性研究
- An investigation of reliability on breast-feeding to infants of hepatitis B virus markers positive mothers by active and passive immunization
- 重庆医科大学学报 2005年第2期页码：275-277
- 作者机构：
  
  1. 重庆医科大学临床学院妇产科
  2. 重庆医科大学临床学院检验科
  3. 重庆医科大学临床学院妇产科,重庆,400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2005.02.032
  中图分类号： R512.6
- 纸质出版日期：2005，
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[1]张建华,王富兰,胡燕,胥飚,邓安菊,蒋丽.乙型肝炎病毒携带产妇预防干预措施与母乳喂养的安全性研究[J].重庆医科大学学报,2005(02):275-277.

ZHANG JianHua, et al. An investigation of reliability on breast-feeding to infants of hepatitis B virus markers positive mothers by active and passive immunization[J]. Journal of Chongqing Medical University, 2005,(2):275-277.
[1]张建华,王富兰,胡燕,胥飚,邓安菊,蒋丽.乙型肝炎病毒携带产妇预防干预措施与母乳喂养的安全性研究[J].重庆医科大学学报,2005(02):275-277. DOI： 10.13406/j.cnki.cyxb.2005.02.032.

ZHANG JianHua, et al. An investigation of reliability on breast-feeding to infants of hepatitis B virus markers positive mothers by active and passive immunization[J]. Journal of Chongqing Medical University, 2005,(2):275-277. DOI： 10.13406/j.cnki.cyxb.2005.02.032.

摘要

目的:调查乙型肝炎病毒（HBV）携带产妇的母乳喂养和人工喂养后婴儿血清HBV标志物（HBVM ）的阳性率

为指导母乳喂养提供证据。方法:用ELISA法检测孕妇和婴儿血清中的HBVM

用荧光定量聚合酶链反应（PCR）法检测HBV携带产妇血清和初乳中HBV -DNA含量

并分析婴儿血清HBVM与母乳喂养和人工喂养的关系。结果:6 7例HBsAg抗原阳性（大、小三阳）

产妇中

HBV血清‘大三阳’的产妇血液、初乳中HBV -DNA阳性率较高。母亲血清HBVM为‘大三阳’者分别占人工喂养组和母乳喂养组的4 1%和13%

两组间有显著性差异（P <0 .0 5 ） ;婴儿在12～18个月时作血清HBVM检测

人工喂养组和母乳喂养组婴儿血清抗-HBs阳性率分别为84 %和87%

两组无显著性差异（P >0 .0 5 ）。结论:只要对HBV携带产妇在孕期进行预防干预及对所产婴儿进行被动和主动免疫防范措施

HBV携带产妇的母乳喂养是相对安全的

Abstract

Objective:To provide evidence instruction for breast-feeding

the investigation of positive rates with serum hepatitis B virus markers(HBVM) in infants of breast-feeding to HBVM positive mothers.Methods:The serum HBVM of pregnant women and their infants were determined by ELISA and HBV-DNA in positive serum and colostrum were determined by fluorescence quantitative PCR.The relation between HBVM in the infant serum and the feeding way was analysed.Results:In 67 parturients with serum HBVM antigen positive

the positive rates of HBV-DNA were 84%

26% and 27%

0% in serum and colostrum with HBeAg positive and HBeAg negative mothers;and there was a positive relationship between the serum and colostrum.The positive rates of HBeAg of mothers were 41% and 13% in the artificial feeding group and breast feeding group

there was significant difference between them( P <0.01).12-18 months after birth

the infants positive rates of serum anti-HBs were 84% and 87% in the artificial feeding group and breast feeding group( P >0.05).Conclusion:The breast-feeding were safe to HBVM positive mothers by active and passive immunization with pregnant women and their infants.

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乙型肝炎病毒母乳喂养聚合酶链反应脱氧核糖核酸

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