：Objective To study the angiographic appearances of malignant bone tumors and to find out an imaging index which can effectively evaluate the curative effect after the combined treatment of intra-arterial infusion and HIFU. Methods The angiographic changes of 27 cases with malignant bone tumors before and after the combined treatment were analyzed. Results The change of the blood lake of the tumor was most distinctive with an improvement rate of 82.6%(19/23). The second important change was the reduction or disappearance of tumor stain (77.3% 17/22). And other appearances have improved in various degrees . Conclusion DSA may be a reliable index to detect the curative effect and evaluate prognosis of malignant bone tumors after the combined treatment.