The interaction between 5-fluorouracil and mitomycin Con human gastric carcinoma cell line (SGc-7901)[J]. Journal of Chongqing Medical University, 2000,(4):352-354.
The interaction between 5-fluorouracil and mitomycin Con human gastric carcinoma cell line (SGc-7901)[J]. Journal of Chongqing Medical University, 2000,(4):352-354. DOI: 10.13406/j.cnki.cyxb.2000.04.007.
:Objective To observe the killing effects of 5-FU and MMC on human gastric carcinoma cell line (SGc-7901). Methods The median-effect principle was used. Results Killing effects of the individual drugs were enhanced as drug concentration increased. The interaction of the two drugs was synergistic at higher concentration (CI<1) and the sequence of administration did not influence the killing effects. Conclusion The interaction of the two drugs was synergistic at higher concentration (CI<1) and antagonistic at lower concentration. (CI>1).
关键词
5-氟脲嘧啶丝裂霉素联合应用中效原理合用指数
Keywords
5-fluorouracilMitomycin CAnticancer drug combinationMedian-effect principleCombination index (CI)