Objective: To investigate the correlation between renal damage and thyroid hormone in patients with chronic renal insufficiency. Methods: 51 cases were divided into three groups---compensation

decompensation and failure. The serum FT 3、FT 4、TT 3、TT 4、rT 3 and TSH levels in all patients were detected by RIA method. Results: The levels of FT 3、FT 4、TT 3、TT 4 were significantly low in patients with serious impairment of renal function (P<0.001). There was a positive correlation between Ccr and TT 3 (r=0.722

P<0.001)

a negative correlation between Scr and TT 3(r=-0.842

P<0.001) in decompensatied group. A positive correlation between Ccr and TT 3、FT 3、TT 4 and anegative correlation between Scr and TT 3、FT 3、TT 4 in group Ⅲ were found. Conclusion: There is a close relationship between levels of serum FT 3、TT 3、TT 4 and renal damage. Change of thyroid hormone might be a marker for evaluation in clinical situation

functional compensation and prognosis of patients with renal insufficiency.