高效液相色谱法测定肝病患者血浆游离色氨酸与总色氨酸的比值

王立; 钮振; 李宗明

doi:10.13406/j.cnki.cyxb.1991.03.005

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高效液相色谱法测定肝病患者血浆游离色氨酸与总色氨酸的比值

更新时间：2024-01-17

- 高效液相色谱法测定肝病患者血浆游离色氨酸与总色氨酸的比值
- DETERMINATION OF FREE AND TOTAL SERUM TRYPTOPHAN IN PATIENTS WITH LIVER DISEASES BY HIGH-PERFORMANCE LIQUIDCHROMATOGRAPHY
- 重庆医科大学学报 1991年第3期页码：193-195
- 作者机构：
  
  重庆医科大学人工肝研究室
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.1991.03.005
  中图分类号：
- 纸质出版日期：1991，
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[1]王立,钮振,李宗明.高效液相色谱法测定肝病患者血浆游离色氨酸与总色氨酸的比值[J].重庆医科大学学报,1991(03):193-195.

DETERMINATION OF FREE AND TOTAL SERUM TRYPTOPHAN IN PATIENTS WITH LIVER DISEASES BY HIGH-PERFORMANCE LIQUIDCHROMATOGRAPHY[J]. Journal of Chongqing Medical University, 1991,(3):193-195.
[1]王立,钮振,李宗明.高效液相色谱法测定肝病患者血浆游离色氨酸与总色氨酸的比值[J].重庆医科大学学报,1991(03):193-195. DOI： 10.13406/j.cnki.cyxb.1991.03.005.

DETERMINATION OF FREE AND TOTAL SERUM TRYPTOPHAN IN PATIENTS WITH LIVER DISEASES BY HIGH-PERFORMANCE LIQUIDCHROMATOGRAPHY[J]. Journal of Chongqing Medical University, 1991,(3):193-195. DOI： 10.13406/j.cnki.cyxb.1991.03.005.

摘要

本文采用HPLC法测定血浆总色氨酸（T-Trp）及经平衡透析法分离的游离色氨酸（F—Trp）.肝硬化组及急性肝炎组的F-Trp和F/T-Trp值均呈显著性增高

对其常规肝功能正常者具有一定诊断价值.应用HPLC测定血浆Trp

方法较简捷可靠

灵敏度及重复性均好

可作为测定血浆色氨酸的一种良好方法

Abstract

In this paper

the determination of T-Trp and F-Trp after equilibrium dialysis in serum by HPLC was reported. Both the serum F-Trp and F/T-Trp ratio were remarkably increased in the patients with cirrhosis and acute viral hepatitis. It was suggested that the determination was valuable in the diagnosis of various liver diseases with normal conventional hepatic function. The analysis of Trp by this method is rather simple with good sensitivity and reproducibility

关键词

高效液相色谱色氨酸肝脏疾病

Keywords

High-performance liquid chromatographyLiver diseaseTryptophan

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