By means of crossed immuno-affinoelectrophresis

serum fucosylated AFP(Fuc AFP)was determined in 167 cases

including primary hepatic carcinoma (PHC) (72 cases)

various liver diseases(54 cases)

other gastrointestinal tumors (4 cases)

and healthy controls (37 cases) .The results showed that serum fucosylation index of AFP (FucI) was significantly higher in PHC than in controls and other diseases (P<0.001). As markers

FucI was useful in the diagnosis of PHC with sensitivity of 84.7% and specificity of 89.5%.The diagnostic positivity was 76.7% in PHC patients with normal or low producing AFP.Through combination of FucI and AFP assa-y

the diagnostic positivity was raised to 90.3%.Marked fall in both FucI and AFP levels were noted in 5 patients with PHC after surgical resection or chemotherapy. In correlation with Edmondson classification of 17 patients with hepatoma

it showed that the serum levels of FucI was higher in well differentiated tumors than in poorly differentiated ones