Objective:To understand the incidence and mortality of colorectal cancer in Chongqing and to provide the suggestion for colorectal cancer prevention and control. Methods:Colorectal cancer cases（ICD-10 code:C18-C21）from 11 cancer registration sites were collected and sorted by the international category of disease（ICD-10）and the international category of tumor（ICD-O-3）. The data were analyzed to calculate the incidence

mortality and age-specific standardized incidence rate and mortality rate by Chinese standard population（ASIRC/ASMRC）and World standard population（ASIRW/ASMRW）and proportion by SPSS 19.0. The difference of the incidence and mortality of colorectal cancer between the male and female

urban and rural area was compared by Chi-square test. The trend of colorectal cancer with age was analyzed by trend Chi-square test（α =0.05）. Results:The incidence of colorectal cancer ranked the second of all cancers in 2015 in Chongqing

which accounted for 10.51% of all cancers. The incidence

ASIRC

ASIRW of colorectal cancer was 28.32/105

17.57/105 and 19.32/105 respectively in 2015. The incidence of colorectal cancer among male residents（32.80/105）was higher than that among female residents（23.74/105）significantly（χ

2

=8.572

P=0.003）. The truncated rate of age 35-64

cumulative rate and cumulative risk of colorectal cancer incidence were 25.77/105

2.10% and 2.08% respectively.The mortality

ASMRC and ASMRW of colorectal cancer were 13.95/105

8.02/105 and 9.33/105 respectively in 2015. The mortality of colorectal cancer among male residents was higher than that among female residents significantly（χ

2

=9.410

P=0.002）. The mortality of colorectal cancer in urban area was higher than that in rural area significantly（χ

2

=6.378

P=0.012）. The truncated rate of age 35-64

cumulative rate and cumulative risk of colorectal cancer mortality were 9.38/105

0.89% and 0.88% respectively. The incidence and mortality of colorectal cancer increased significantly with the age（χ

2

=14.533

P=0.000;χ

2

=11.398

P=0.001）. The incidence of colorectal cancer increased rapidly after 40 years old and its mortality increased rapidly after 50 years old. Conclusion:The incidence and mortality of colorectal cancer is high in Chongqing municipality. Great importance should be attached to tertiary prevention for colorectal cancer.