浏览全部资源
扫码关注微信
射波刀治疗肝癌对外周血淋巴细胞的影响
Effect of CyberKnife radiotherapy on peripheral blood lymphocytes of liver cancer
- 局解手术学杂志 2024年33卷第1期 页码：73-75
- 作者机构：
1.中国人民解放军联勤保障部队第九四〇医院肿瘤科，甘肃 兰州 730050
2.中国人民解放军联勤保障部队第九四〇医院放疗科，甘肃 兰州 730050
- 作者简介：
张 超，E-mail：47723150@qq.com
- 基金信息：甘肃省自然科学基金项目(22JR5RA003)
DOI：10.11659/jjssx.02E023021
中图分类号： R735.7纸质出版日期：2024-01-25，
收稿日期：2023-02-03，
扫 描 看 全 文
傅华,魏莹,李莎等.射波刀治疗肝癌对外周血淋巴细胞的影响[J].局解手术学杂志,2024,33(01):73-75.
FU Hua,WEI Ying,LI Sha,et al.Effect of CyberKnife radiotherapy on peripheral blood lymphocytes of liver cancer[J].JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY,2024,33(01):73-75.
傅华,魏莹,李莎等.射波刀治疗肝癌对外周血淋巴细胞的影响[J].局解手术学杂志,2024,33(01):73-75. DOI： 10.11659/jjssx.02E023021.
FU Hua,WEI Ying,LI Sha,et al.Effect of CyberKnife radiotherapy on peripheral blood lymphocytes of liver cancer[J].JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY,2024,33(01):73-75. DOI： 10.11659/jjssx.02E023021.
摘要
目的
2
探讨射波刀治疗的不同分割剂量、分割方式等相关参数对肝癌患者外周血淋巴细胞计数的影响。
方法
2
回顾性分析在我院使用射波刀治疗的90例肝癌患者的临床资料。检测患者射波刀治疗前1周及治疗后1周、1个月、3个月的外周血淋巴细胞计数；分析射波刀不同处方剂量、分割剂量、分割次数对外周血淋巴细胞计数的影响。
结果
2
与治疗前1周比较，不同处方剂量、分割剂量及分割方式的患者在射波刀治疗后外周血淋巴细胞计数出现不同程度下降(
P
<
0.05)。治疗后1周、1个月，分割次数≤5次组和分割剂量
>
7 Gy组患者的外周血淋巴细胞计数分别显著高于分割次数
>
5次组和分割剂量≤7 Gy组(
P
<
0.05)。不同处方剂量的患者在射波刀治疗前后淋巴细胞计数差异无统计学意义(
P
>
0.05)。
结论
2
射波刀治疗肝癌时给予分割次数≤5次、分割剂量>7 Gy的治疗方案，更有利于减轻射波刀治疗所导致的淋巴细胞数量下降。
Abstract
Objective
2
To explore the effects of different fractionation doses，fractionation methods，and other related parameters on the peripheral blood lymphocyte count of patients with liver cancer receiving CyberKnife radiotherapy.
Methods
2
The clinical data of 90 patients with liver cancer receiving CyberKnife radiotherapy in our hospital were retrospectively analyzed. The peripheral blood lymphocyte counts of patients 1 week before CyberKnife radiotherapy and 1 week，1 month and 3 months after treatment were determined. The effects of different prescribed doses，fractionation doses and numbers of fractionations on the peripheral blood lymphocyte count were analyzed.
Results
2
The peripheral blood lymphocyte counts of patients with different prescribed doses，fractionation doses and fractionation methods after CyberKnife treatment decreased to varying degrees compared with those 1 week before treatment （
P
<
0.05）. The peripheral blood lymphocyte counts of patients in the groups with ≤5 fractionations and fractionation dose
>
7 Gy were significantly higher than those of patients in the groups with
>
5 fractionations and the fractionation dose≤7 Gy，respectively （
P
<
0.05）. There was no significant difference in peripheral blood lymphocyte counts between patients with different prescribed doses before and after CyberKnife treatment （
P
>
0.05）.
Conclusion
2
CyberKnife in the treatment of liver cancer with ≤5 ractionations and a fractionation dose of >7 Gy is more beneficial to alleviate the decrease of lymphocyte count caused by Cyberknife treatment.
关键词
肝癌射波刀淋巴细胞计数免疫治疗
Keywords
liver cancerCyberknifelymphocyte countimmunotherapy
references
Torre LA，Bray F，Siegel RL，et al.Global cancer statistics，2012［J］.CA：A Cancer J Clin，2015，65（2）：87-108.doi：10.3322/caac.21262http://dx.doi.org/10.3322/caac.21262.
Chen W，Zheng R，Baade PD，et al.Cancer statistics in China，2015［J］.CA：A Cancer J Clin，2016，66（2）：115-132.doi：10.3322/caac.21338http://dx.doi.org/10.3322/caac.21338.
Takeda A，Sanuki N，Tsurugai Y，et al.Phase 2 study of stereotactic body radiotherapy and optional transarterial chemoembolization for solitary hepatocellular carcinoma not amenable to resection and radiofrequency ablation［J］.Cancer，2016，122（13）：2041-2049.doi：10.1002/cncr. 30008http://dx.doi.org/10.1002/cncr.30008.
乔敏，赵一鉴，张建巧，等.TACE联合射频消融治疗原发性肝癌患者疗效研究［J］.实用肝脏病杂志，2021，24（1）：119-122.doi：10.3969/j.issn.1672-5069.2021.01.031http://dx.doi.org/10.3969/j.issn.1672-5069.2021.01.031.
Nishiga Y，Drainas AP，Baron M，et al.Radiotherapy in combination with CD47 blockade elicits a macrophage-mediated abscopal effect［J］.Nat Cancer，2022，3（11）：1351-1366.doi：10.1038/s43018-022-00456-0http://dx.doi.org/10.1038/s43018-022-00456-0.
丛文铭，步 宏，陈 杰，等.原发性肝癌规范化病理诊断指南（2015版）［J］.临床与实验病理学杂志，2015，31（3）：241-246.doi：10.13315/j.cnki.cjcep. 2015. 03.001http://dx.doi.org/10.13315/j.cnki.cjcep.2015.03.001.
Long J，Bai Y，Yang X，et al. Construction and comprehensive analysis of a ceRNA network to reveal potential prognostic biomarkers for hepatocellular carcinoma［J］.Cancer Cell Int，2019，19：90.doi：10.1186/s12935-019-0817-yhttp://dx.doi.org/10.1186/s12935-019-0817-y.
Michael D. Checkpoint blockade toxicity and immune homeostasis in the gastrointestinal tract［J］.Front Immunol，2017，8：1547.doi：10.3389/fimmu.2017.01547http://dx.doi.org/10.3389/fimmu.2017.01547.
Kuol N，Stojanovska L，Nurgali K，et al.PD-1/PD-L1 in disease［J］.Immunotherapy，2018，10（2）：149-160.doi：10.2217/imt-2017-0120http://dx.doi.org/10.2217/imt-2017-0120.
Zheng X，Hu Y，Yao C，et al.The paradoxical role of tumor-infiltrating immune cells in lung cancer［J］.Intractable Rare Dis Res，2017，6（4）：234-241.doi：10.5582/irdr.2017.01059http://dx.doi.org/10.5582/irdr.2017.01059.
Talebian Yazdi M，van Riet S，van Schadewijk A，et al.The positive prognostic effect of stromal CD8+ tumor-infltrating T cells is restrained by the expression of HLAE in non-small cell lung carcinoma［J］.Oncotarget，2016，7（3）：3477-3488.doi：10.18632/oncotarget.6506http://dx.doi.org/10.18632/oncotarget.6506.
Thomas PD，Kahn M.Kat3 coactivators in somatic stem cells and cancer stem cells：biological roles，evolution，and pharmacologic manipulation［J］. Cell Biol Toxicol，2016，32（1）：61-81.doi：10.1007/s10565-016-9318-0http://dx.doi.org/10.1007/s10565-016-9318-0.
Wild AT，Herman JM，Dholakia AS.Lymphocyte-sparing effect of stereotactic body radiation therapy in patients with unresectable pancreatic cancer［J］.Int J Radiat Oncol Biol Phys，2016，94（3）：571-579.doi：10.1016/ j.ijrobp.2015.11.260http://dx.doi.org/10.1016/j.ijrobp.2015.11.260.
Crocenzi T，Cottam B，Newll P，et al.A hypofractionated radiation regimen avoids the lymphopenia associated with neoadjuvant chemoradiation therapy of borderline resectable and locally advanced pancreatic adenocarcinoma［J］.J Immunother Cancer，2016，4： 45.doi： 10.1186/s40425-016-0149-6http://dx.doi.org/10.1186/s40425-016-0149-6.
Brown J，Carlson D，Brenner D，et al.The tumor radiobiology of SRS and SBRT：are more than the 5 Rs involved？［J］.Int J Radiat Oncol Biol Phys，2014，88（2）：254-262.doi：10.1016/j.ijrobp. 2013.07.022http://dx.doi.org/10.1016/j.ijrobp.2013.07.022.
Greten TF，Sangro B.Targets for immunotherapy of liver cancer［J］.J Hepatol，2017，68（1）：157-166.doi：10.1016/j.jhep.2017.09.007http://dx.doi.org/10.1016/j.jhep.2017.09.007.
Cho Y，Park S， Byun HK，et al.Impact of treatment-related lymphopenia on immunotherapy for advanced non-small cell lung cancer［J］.Int J Radiat Oncol Biol Phys，2019，105（5）：1065-1073.doi：10.1016/j.ijrobp.2019.08.047http://dx.doi.org/10.1016/j.ijrobp.2019.08.047.
Jiang X，Xu J， Liu M，et al.Adoptive CD8+ T cell therapy against cancer： challenges and opportunities［J］.Cancer Lett，2019，462（10）：23-32.doi：10.1016/j.canlet.2019.07.017http://dx.doi.org/10.1016/j.canlet.2019.07.017.
Bonta I，Isac JF，Meiri E，et al.Correlation between tumor mutation burden and response to immunotherapy［J］.J Clin Oncol，2017，35（15_suppl）：e14579.doi： 10.1200/JCO.2017.35.15_suppl.e14579http://dx.doi.org/10.1200/JCO.2017.35.15_suppl.e14579.
Yau T，Kang YK，Kim TY，et al.Nivolumab （NIVO）+ipilimumab（IPI） combination therapy in patients（pts） with advanced hepatocellular carcinoma （aHCC）：results from CheckMate040［J］.J Clin Oncol，2019，37（15_suppl）：4012. doi： 10.1200/JCO.2019.37.15_suppl.4012http://dx.doi.org/10.1200/JCO.2019.37.15_suppl.4012.
Deng L，Liang H，Burnette B，et al.Irradiation and anti-PD-L1 treatment synergistically promote anti-tumor immunity in mice［J］.J Clin Invest，2014，124（2）：687-695.doi：10.1172/JCI67313http://dx.doi.org/10.1172/JCI67313.
0
浏览量
4
下载量
0
CSCD
- 网络PDF下载
- WORD下载
- Meta-XML下载
- BibTeX下载
- Endnote下载
- RefMan 下载
- NoteExpress下载
- NoteFirst下载
关联资源
相关文章
相关作者
相关机构
- 技术支持由北京北大方正电子有限公司提供 京ICP备09064830号-19
京公网安备11010802024621 - 本系统建议在Chrome、 IE9+ 以上版本浏览器阅读本站内容，360浏览器请切换至极速模式
- Cookies帮助我们提供服务并提供个性化体验。使用本网站，即表示您同意我们使用Cookies
