Objective　To explore the effective way of first aid skill standard training in regional central hospital. Methods　60 residents from different regional central hospitals were received aid skills training based on two ways: namely OSCE （multi-station structured skills test） which lay particular emphasis on skills and traditional face to face way； and were assessed by uniform standards. Results　The scores of residents who received OSCE training were significantly better than those which received tradi-tional face to face training （P<0.05）， including. ECG， cardiopulmonary resuscitation， endotracheal in-tubation and doctor examination. Conclusion　First aid skills standard training used by OSCE approach in regional central hospital can improve their first aid skills and should be promoted.