Objective　To analyze the effectiveness of doctor-patient communication course on improvement of doctor-patient communication ability. Methods　Totally 360 eight-year program medi-cal students of clinical medicine from Shanghai Jiaotong University School of Medicine were chosen as the research object and were divided into educational group（n=180） and control group（n=180）. Stu-dents in educational group study doctor-patient communication course while those in control group do not. SEGUE Framework was used to conduct exploratory research between educational group and control group. Accuracy of questionnaire database was examined by Excel software and logical test. Kolmogorov-Smirnov（K-S test） was applied to analyze the scores and （x±s） was used to express the data through SPSS 16.0 statistical software. Comparison between group differences are statistically significant（P<0.05）. Results　Overall score was higher in educational group than in control group. Concerning of communication initiation， information collection and understanding of patients， scores of educational group were significantly higher than those of control group（P=0.001， P=0.002 and P=0.007， respec-tively）. Furthermore， Kolmogorov-Smirnov（K-S test） and （x±s） statistical results showed that scores of detailed items were higher in educational group than in control group as well. Conclusions　Doctor-patient communication course is of great importance to help medical students practice physician-patient communication based on related knowledge learning， but course content setting re－mains to be further improved.