Objective　To apply the ‘organ-systems-based curriculum’ （OSBC） medical teaching method in clinical novitiate curriculum， to conduct an OSBC oriented clinical curriculum re-form and to observe its effectiveness. Methods　Daping Hospital of the Third Military Medical Univer-sity implemented the curriculum reform on the medical undergraduates of class 2010 during the aca-demic year 2012-2013. The traditional teaching departments based on disciplines were dissolved and new teaching groups were built up based on organ/systems. The curriculums were integrated and jointed teaching was carried out. The effectiveness of the reformed and traditional curricula were compared by assessing the satisfaction and the average test scores. Two-way ANOVA and student's t test （SPSS 19.0 software） were used for statistical analysis. Results　Compared with those of previous two classes， OSBC reform reduced the total hours of the circulatory system from 57 hours to 50 hours， increased the students’ satisfaction （class 2008： 90.4%（142/157） vs. class 2009： 91.4% （64/70） vs. class 2010： 97.2%（171/176））， promoted the average test scores [class 2008： （69.1±6.5） vs. class 2009： （69.5±7.2） vs. class 2010： （78.9±6.2）] and improved the students' learning interests and clinical thinking ability. Conclusions　The OSBC oriented clinical curriculum reform showed significant ad-vancement and fair feasibility， which significantly improved the quality of teaching and learning there-by achieving an initial success.