Objective　To study the application of standardized patients practice and agent physician system in digestion medical clinical practice. Methods　One hundred and fifty five-year-clinical medical students who began digestion medical clinical practice from 2008 to 2009 were selected and randomly divided into teaching reform group and control group， each group containing 75 people. According to teaching reform group students' willingness and through the selection， 69 were identified as agent physician. Standardized patients and agent physician simulation clinical training were applied in the teaching reform group while conventional teaching methods were used in the control group. Sta-tistical analysis of the experimental data was conducted using SPSS 11.0 statistical package. Measure-ment data use independent-samples t test and rank sum test was used for heterogeneity of variance. Results　Teaching reform group students' inquiry contents and skills scores for each project were higher than those of control group and the score difference was statistically significant（P<0.05） in chronological order， the transition language， interrogation schedule， repeated questions， summary records， citing verification， instrumentation courtesy， friendly behavior， praise and encouragement， eliciting the patient's views， concerns about the effects of disease， care and support and assistance aspects. After the end of the third internship， two groups were compared in operation results， reform history collection， physical examination skills group score and the excellent and good rate being higher（P=0.002， 0.001）. After three times' practice， teaching group students' scoring pass rate in medical ethics demeanor， interrogation techniques and physical examination skills， case analysis is higher than that of the control group students， and the difference was statistically significant（P<0.05）. Conclusion Application of standardized patients and implementing agency resident simulation clinical training in the guide teaching of digestion department of internal medicine has achieved good effect.