Objective: To compare the influence of haemodynamic and hormonic responses to induction and endotracheal intubation with propofol

thiopental and etomidate. Methods: 30 patients were divided randomly into three groups ( n =10). Anesthesia was induced with either propofol 2mg/kg ( groupⅠ)

thiopental 5mg/kg ( groupⅡ) or etomidate 0.3mg/kg ( groupⅢ)

together with fentanyl 3μg/kg and vecuronium 0.1mg/kg for endotracheal intubation. Results: The HR of group I was decreased (Ｐ>0.05) after induction

the groups Ⅱ and III heart rate were increased significantly during the intubation

(Ｐ<0.05 ). The MAP of group Ⅰ was decreased after induction

( Ｐ<0.05 ). The group Ⅱ MAP had decreased after induction and increased during and after 4min intubation

( Ｐ<0.05 ). The group Ⅲ MAP was increased during intubation

( Ｐ<0.05 ). In groups Ⅱ and Ⅲ

both cortisol and insulin were increased obviously after intubation for 4 min

(Ｐ<0.05) In all the three groups

the blood sugar was not significantly increased after intubation

( Ｐ>0.05). Conclusion: Haemodynamic and hormonic responses are less in propofol group than in thiopental and etomidate group during induction and intubation and it is useful for anesthesia to do the induction with propofol.