Objective:To explore the effect of bone marrow stem cell mobilization in resolution of deep vein thrombosis.Methods:The SD adult rats were randomly divided into normal

sham

surgical and mobilization group(with subcutaneous injection of rhG-CSF).The peripheral blood mononuclear cell count

pathological change and thrombus organization rate in different time were examined.Results:The peripheral blood mononuclear cell count in mobilization group was significantly elevated

and there was no significant change in other groups.Compared with surgical group

there were more inflammatory cells in thrombus of mobilization group at 7th postoperative day

and the organization area of thrombus was wider and the organization rate was significantly different in mobilization group at 14th postoperative day(P<0.05).Conclusion:The bone marrow stem cell mobilization contribute to the resolution of deep vein thrombosis.