GAO Han, et al. The application of five serum markers in therapeutic effectiveness evaluation with breast cancer[J]. Journal of Chongqing Medical University, 2007,(6):623-625.
GAO Han, et al. The application of five serum markers in therapeutic effectiveness evaluation with breast cancer[J]. Journal of Chongqing Medical University, 2007,(6):623-625.DOI:
Objective:To approach the change of five serum markers such as CA15-3、CA125、CEA、CYFRA21-1 and TPS with breast cancer between pre-and post-neoadjuvant chemotherapy
to screen the better treatment effectiveness evaluation markers.Methods:The serum markers such as CA15-3、CA125、CEA、CYFRA21-1 and TPS of 48 cases with breast cancer were detected by enzyme linked immunosorbent assay respectively pre-and post-neoadjuvant chemotherapy.Results:In effective group
CA15-3、CYFRA21-1 and CEA were significantly decreased(P<0.05)
but in ineffective group
CA15-3、CA125、CEA、CYFRA21-1 and TPS had no obviously change(P>0.05).Through Logistic multiple factor regression analysis
CA15-3?CYFRA21-1and CEA were the better markers of among the five markers to evaluate the neoadjuvant chemotherapy efficacy of breast cancer
and evaluate role from strong to poor by turns.Conclusion:CA15-3 was the best marker of five serum markers to evaluate the neoadjuvant chemotherapy efficacy of breast cancer.