Objective:To comparing the pharmacokinetics of cisatracurium with different dose in rabbits undergoing three kinds of body temperature.Methods:72 healthy rabbits weighing 2.0～2.3 kg were used in this study.They were randomly allocated to normothermia group(C)

hyperthermia group(H)

hypothermia group(L)

each was with 24 rabbits.rectal temperature of C

H and L groups were 38.5

41.8 and 34.5℃.Each group was also allocated to group Ⅰ

Ⅱ

Ⅲ and Ⅳrandomly(n=6).The doses in Ⅰ～Ⅳ groups were 0.33

0.66

0.99and1.32 mg/kg cisatracurium respectively.Blood samples were taken from jugular vein at 2

4

6

8

10

12

15

20

30

60

90

120 min after injection.The plasma concentration of cisatracurium was detected by HPLE.Elimination half life(t1/2β) and elimination rate constant(kβ) were calculated by 3p97 pharmacokinetics software.Results:The t1/2β and maximum concentration(Cmax) were significantly increased in L group and were significantly decreased in H group(P<0.05

P<0.01).The kβ was significantly decreased in L group and increased in H group(P<0.01).The t1/2β and kβ were not significantly distinct among different dose groups.Following to initial dose of rabbits steping up

Cmax was increased(P<0.05

P<0.01).Conclusion:The Pharmacokinetics of cisatracurium in rabbit are changed by body temperature.Following to body temperature of rabbits steping up

the degradation rate of cisatracurium is speeded up

while the t1/2β is cut down.The t1/2β and kβ are not significantly distinct among doses range from 0.33 to 1.32mg/kg.The pharmacokinetics characteristic of cisatracurium is predictablely well.