Objective:To study the clinicopathologic features、diagnosis and differential diagnosis of epithelioid sarcoma.Methods:Two cases of epithelioid sarcoma were collected according to the classification of soft tissue and bone tumors(WHO

2002) and were studied by hematoxylin-eosin and immunohistochemical staining.Results:One case was proximal type epithelioid sarcoma

and the other distal type epithelioid sarcoma.The case of distal type epithelioid sarcoma was female

twenty eight years old

and the site was the left leg;histological structure was the typical pseudo-granuloma formation

the tumor cells resembled epithelioid cells

with necrosis in the center.The case of proximal type epithelioid sarcoma was female

thirty six years old

and the site was the cervix;nodal formation can be observed

the tumor cells resembled spindle cells

abd the extent of necrosis was bigger.For the immunohistochemical staining

expressions of Vimentin、EMA and CK antigen were observed in the 2 cases

while expressions of Desmin、NSE and S-100 antigen were negative.Moreover

expressions of low CK and CD34 antigen were also observed in the case of distal type epithelioid sarcoma.On the other hand

expressions of Actin、SMA and HMB-45 antigen were not observed in the case of proximal type epithelioid sarcoma.Conclusions:Epithelioid sarcoma is a rare maliglant tumor of soft tissue

It’s the key for diagnosis and differential diagnosis to combine clinic、histological structure、immunophenotype and prognosis together.