Objective:To determine the clinical pharmacokinetics of cisatracurium besilate

and its effects on hepatic function and renal function in Chinese patients.Methods: Thirty ASA Ⅰ～Ⅲ

patients undergoing elective surgery were enrolled in this study.Anesthesia was induced by a single injection of cisatracurium 0.15mg/kg.The change of heart rate

blood pressure

skin condition and TOF were observed.When T1 reached the maximum block effect

condition of intubation were appraised and recorded.The inhibition and recovery process of adductor pollicis muscle to stimulation of ulnar nerve with TOF pulses was recorded.Times to T4/T1 inhibition and recovery to 25%

75% and 100% were noted.Which were the observing index for muscle relaxation.Hepatic function and renal function were determined after 24 hours.Results: AS the maximum block effect was 100%intubation completed.Grade one was 93.3%(28cases)

and grade two was 6.7(% 2cases).No erubescent phenomenon and bronchitis spasm were discovered.After induction of anesthesia

HR and BP decreased significantly(P<0.05).Hepatic function and renal function had no obvious change after operation.Average time of T4/T1 depressed to 100% was(4.46± 0.91) min

the average time of recovery to 25% and 100% were(42.02±6.73) min

and(64.69±9.47) min.respectively.And the recovery index of 25%～75% was(11.59±3.11) min.Conclusion: Intravenous administration of cisatracurium 0.15mg/kg(3× ED95) can he safely used for induction of general anesthesia.Which offers satisfactory muscle relaxation;and has no obvious effects on BP

HR

hepatic and renal functions in Chinese patients.