Objective:To explore clinical significance of the further method dealt with in ASCUS(atypical squamous cells undetermined significance) of cervical smear.Methods:118 patients with ASCUS were detected by colposcopy and high risk HPV test

simultaneously make biopsy of cervical guided by colposcopy.Result:By diagnosed with pathology

chronic cervical inflammation is 72 cases

46 cases were CIN(cervical intraepithelial neoplasia).In this study 40 cases were positive in HPV test which 33 cases are CIN(χ2=48.18

P<0.05).Comparae the sensitivity of Human papillomavirus(HPV) test with colposcopy has no significance(71.74% vs 78.26%;P>0.05).Conclusion:There are high CIN csses in Women with ASCUS whose should be paid attention to and strengthen management.Colposcopy and high risk HPV test are efficiency method to ASCUS

especially high risk HPV test is positive that need detective by colposcopy.The combination of colposcopy and high risk HPV test can improve detective rate and accuracy of cervical intraepithelial neoplasia(CIN).