Objective:To investigate the effect of PHB/PEO polymer combined with nerve growth factor in the peripheral nerve injury.Method:The male SD rats were treated with autogentic neural transplantation

xenogenic neural transplantation under the immunosuppression

transplantation of PHB/PEO polymer combined with nerve growth factor and PHB/PEO guidance transplantation

respectively.The nerve function and the nerve anatomic structure were evaluated by the sciatic function index(SFI)

nerval electrophysiology test

nerve fiber number and electron microscope.Result:The SFI

nerve conduction velocity

nerve fiber number and the regeneration of nerve fiber and myeline sheath of the PHB/PEO polymer combined with nerve growth factor group is similar to the autogentic neural transplantation group

and is better than the xenogenic neural transplantation group and PHB/PEO guidance group significantly.Conclusion:The effect of PHB/PEO polymer combined with nerve growth factor is similar to the autogentic neural transplantation

and is better than the xenogenic neural transplantation and PHB/PEO guidance significantly in the repair of sciatic nerve injury.