Objective:To compare characters of urethral healing after different surgical procedures to provide theoretical support for preventing and curing urethral scaring stricture after hypospadias repair.Methods:Hypospadiac animal model was established and three surgical procedures were adopted to repair urethra.The dynamic changes of urethral healing and scar were observed

the expressions of α-SMactin and TGF-β1 were examined.Results:Mathieu and Onlay island flap(Onlay) had notable collagenous proliferation

which was significantly stronger than that of Tubularized Incised Plate urethroplasty(TIPU)(P<0.05).The expressions of TGF-β1 and α-SMactin were markedly higher in Mathieu and Onlay than that in TIPU at 6 weeks and 3 months.Conclusion:TIPU is a comparatively ideal surgical procedure since urethra repaired by TIPU is more similar to normal anatomy and urethral scar proliferation was less than that in Mathieu and Onlay urethroplasty.The activity of fibroblasts kept long in all these urethroplasties

which may be the pathological foundation for the formation and gradual aggravation of urethral stricture following hypospadiac repair.