Objective:To investigate the effect of curcumin on the proliferation and the protein expression of Pleiotrophin(PTN) in cervical cancer Caski cells. Methods:MTT was used to assay the proliferation of Caski cells which were treated with different concentrations of curcumin. The immunocytochemistry was used to assay the distinctive expression of PTN in Caski cells which were treated by curcumin or not. The effects of curcumin with different concentrations on the protein levels of PTN were tested by Western blotting. Results:The proliferation of Caski cells were inhibited by curcumin in a does-dependent manner.Immunocytochemistry assessment showed the expression of PTN was significant down-regulated after treated with curcumin. Western blotting showed the curcumin could down-regulate the expression of PTN

and this was a does-dependent action. Conclusion:Curcumin could inhibit the proliferation and the PTN expression of Caski cells significantly

which may be one of the molecular mechanisms anticancer of curcumin.