Objective:To observe the effects of Jianweiyuyang(JWYY) pills on expressions of spasmolytic Polypeptide(SP)and intestinal trefoil factors(ITF) and analyze its potential mechanism. Methods:A Total of 76 gastric ulcer patients(final diagnosis by gastroscope)

were randomly divided into two groups

JWYY treatment group

(36 cases

treatment group) and Ranitidine control group(36 samples

control group).Among them 50 Hp-positive PU patients were confirmed by gastroscope

histological inspection

and urease test

and showed the differentiation of symptoms and signs of the traditional Chinese medicine is the stagnation of liver-QI with deficiency of the spleen type for these 50 patients. There were 12 case in Normal groups.Detection on Biospy Specimens of gastric mucosa was done.The change of SP expression was detected by immunohischemicity

ITF by Western blotting and the contents of aninohexose and phosphatide in ulcerated gastric mucosa were measured. Results:The contents of aninohexose and phosphatide of PU patients increased in JWYY group and there was significant difference between JWYY group and Ranitidine group(P<0.01). The immunohischemicity and Western blotting method showed that there has a Linear correlation between the the contents of phosphatide and aninohexose and the expressions of SP and ITF in PU patients(P<0.01). Conclusion:JWYY pills can prevent the occurrence and relapes of ulcer

affect the hydrophobicity of gastric mucosa and strengthen the stability of myxogellayer by elevating the expressions of ITF and SP

and effecting the contents of phosphatide and aninohexose. This is probably one of the main mechanisms of JWYY to heal ulcer quickly.