Objective:Tow kinds of Polycystic Ovary Syndrome models in rats were compared.Methods:In the model ⅰ

ten female rats were given DHEA+INS.In the model ⅱ

ten female rats were given HCG+INS.Then the ovulation

morphology of ovary

blood serum levels of sexual hormones

fasting plasma glucose(FPG)

fasting insulin(FINS) in the two models were assyed

Results:There were 90 percent of rats losting regular estrous cycle in the model ⅰand 100 percent of rats in the model ⅱ.The ovary weight of rats in both two models was heavier than that of controls.Rats of both two models showed polycystic ovary-like syndrome manifestation

The average saccular ovulas in model ⅰ(0.048±0.012) was smaller than those in model ⅱ(0.069±0.036)

The number of corpora lutea in modelⅰ(0.10±0.32) was smaller than that in model ⅱ(0.70±0.82).Serum levels of T

LH/FSH increased in both two model.Serum levels of E2 had no significant increase(P>0.05).HOMA-IR of both two models were higher than that of controls with model ⅰ(8.89±0.86) significantly higher than model ⅱ(6.86±0.48). Conclusion:The model of DHEA+INS is more similar to human PCOS in the morphology of ovary and the degree of insulin resistance.