Objective:To study the association between rs1135791、rs722555、rs116799831、rs3948464 polymorphisms of Sp110 gene and susceptibility to tuberculosis of Han people in Chongqing.Methods:Using case-control study

rs1135791、rs722555、rs116799831、rs3948464 polymorphisms of Sp110 gene were detected.The test of significance was performed with the computer program

SAS Version 8.2.Results:(1)The frequencies of rs1135791 CT、rs722555 GG、rs116799831 GG、rs3948464 CC had statistically significant difference between the case and the control group.(2)The frequencies of rs1135791 C allele、rs722555 G allele、rs116799831 G allele、rs3948464 C allele had statistically significant difference between the case and the control group.Conclusion:The rs1135791 C/T、rs722555 A/G、rs116799831 A/G、rs3948464 C/T polymorphisms of Sp110 gene were possibly susceptible to the tuberculosis of the Han people in Chongqing.