Objective:To investigate the protective role of Shenfu injection(SF) in ischemia-reperfusion injury of transplanted livers in rats.Methods:48 male SD rats

weighted 200~230g

were selected and divided into control group and SF group at random.All of them were performed liver transplantation.2h

4h and 6h after the transplantation

they were analyzed for level of biliation

serum alanine aminotransferase

tumor necrosis factor-α(TNF-α)

NF-κB expression in hepatic tissue and the morphological observation of hepatic tissue under light/electron microscope.Results:At each phase

biliation in SF group was significantly higher than in control group(P<0.05);serum levels of ALT and TNF-α

NF-κB expression in hepatic tissue of SF group were significantly lower than in control group(P<0.05).At each phase

hepatic injury in SF group was significantly lighter than in control group under light/electron microscope.Conclusion:Shenfu injection can significantly palliate the injury of liver structure and function after liver transplantation

and enhance the tolerance of organism to ischemia-reperfusion injury.