Objective:To study the formation of lesions

caused byHIFU with SonoVue

in liver tissues containing blood vessels with the diameter of about 3mm.Methods:The livers of ten goats were insonicated linearly by Model-JC focused ultrasound tumour therapeutic system.The target regions contained blood vessels with the diameter of about 3mm

with or without SonoVue.24 hours after the insonication

the goats were executed with overdosage anesthetics.The length

width and thickness of the lesions were measured

then the necrosies volumes with and without SonoVue were compared.Results:When the depth was 30mm

and the target regions caotained large blood vessels

HIFU with SonoVue could form lesions effectively.There was difference of necrosis volumes between lesions with and without SonoVue

and the difference was significan(tP<0.05).Conclusions:When the target tissues contain large vessels

SonoVue can in- crease the efficacy of HIFU

and form lesions effectively.