WU Lu-chun, et al. Determination of ionization equilibrium constant for insulin-sensitizer rosiglitazone free base[J]. Journal of Chongqing Medical University, 2009,34(11):1546-1548.
WU Lu-chun, et al. Determination of ionization equilibrium constant for insulin-sensitizer rosiglitazone free base[J]. Journal of Chongqing Medical University, 2009,34(11):1546-1548.DOI:
Objective:To establish a method for determination of ionization equilibrium constant of insulin-sensitizer rosiglitazone free base.Methods:Methanol solutions of Rosiglitazone free base with pH values of 1.64
5.76
6.41
6.91
7.14
7.46 and 10.64 were respectively scanned at the wavelength within the range of 200~400 nm.The absorbance and pKa value of rosiglitazone were determined at the selected wavelength of 312
317
326 and 330nm respectively.Results:The ionization equilibrium constant value of rosiglitazone free base was 7.09.Conclusion:The present method is convenient and applicable for determination of pKa 2~9 of drugs.