花子地黄汤联合贝那普利对糖尿病肾病患者肾功能、中医证候及微循环指标的影响

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花子地黄汤联合贝那普利对糖尿病肾病患者肾功能、中医证候及微循环指标的影响

临床医学 | 更新时间：2022-11-04

- 花子地黄汤联合贝那普利对糖尿病肾病患者肾功能、中医证候及微循环指标的影响
- Effects of huazi dihuang decoction combined with benazepril on renal function, TCM symptoms and microcirculatory indexes in patients with diabetic nephropathy
- 保健医学研究与实践 2022年19卷第4期页码：32-37
- 作者机构：
  
  辽宁中医药大学附属医院肾内科
- 作者简介：
- 基金信息：
  
  辽宁省自然科学基金指导计划(20170540607)
- DOI：
  中图分类号： R587.2;R692.9
- 纸质出版日期：2022，
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范菁, 远方. 花子地黄汤联合贝那普利对糖尿病肾病患者肾功能、中医证候及微循环指标的影响[J]. 保健医学研究与实践, 2022,19(4):32-37.

Fan Jing, Yuan Fang. Effects of huazi dihuang decoction combined with benazepril on renal function, TCM symptoms and microcirculatory indexes in patients with diabetic nephropathy[J]. Health Medicine Research and Practice, 2022,19(4):32-37.
范菁, 远方. 花子地黄汤联合贝那普利对糖尿病肾病患者肾功能、中医证候及微循环指标的影响[J]. 保健医学研究与实践, 2022,19(4):32-37. DOI：

Fan Jing, Yuan Fang. Effects of huazi dihuang decoction combined with benazepril on renal function, TCM symptoms and microcirculatory indexes in patients with diabetic nephropathy[J]. Health Medicine Research and Practice, 2022,19(4):32-37. DOI：

摘要

目的探讨花子地黄汤联合贝那普利对糖尿病肾病(DN)患者肾功能、中医证候及微循环指标的影响。方法选取2018年8月—2020年8月沈阳市某医院收治的147例DN患者为研究对象

采用随机数字表法分为观察组、对照1组、对照2组

每组49例。观察组患者给予花子地黄汤联合贝那普利治疗

对照1组患者给予花子地黄汤治疗

对照2组患者给予贝那普利治疗

3组患者均持续治疗12周。比较3组患者治疗后临床疗效;比较3组患者治疗前后肾功能、中医证候积分、血液微循环指标;比较3组患者治疗期间不良反应发生情况。结果观察组、对照1组、对照2组患者临床治疗总有效率分别为93.88%、79.59%、79.59%

观察组高于对照1组、对照2组

差异均有统计学意义(P<0.05)。治疗前

3组患者尿微量白蛋白(m ALB)、尿素氮(BUN)、血肌酐(Scr)水平比较

差异均无统计学意义(P>0.05);治疗后

3组患者m ALB、BUN及Scr水平均低于治疗前

且观察组低于对照1组、对照2组

差异均有统计学意义(P<0.05);治疗后

对照1组患者m ALB、BUN及Scr水平均低于对照2组

差异均有统计学意义(P<0.05)。治疗前

3组患者头晕耳鸣、心悸气短、倦怠无力、盗汗、自汗等中医证候积分比较

差异均无统计学意义(P>0.05);治疗后

3组患者头晕耳鸣、心悸气短、倦怠无力、盗汗、自汗等中医证候积分均低于治疗前

且观察组低于对照1组、对照2组

差异均有统计学意义(P<0.05);治疗后

对照1组患者头晕耳鸣、心悸气短、倦怠无力、盗汗、自汗等中医证候积分均低于对照2组

差异均有统计学意义(P<0.05)。治疗前

3组患者红细胞聚集指数、全血黏度低切、全血黏度中切、全血黏度高切指标比较

差异均无统计学意义(P>0.05);治疗后

3组患者红细胞聚集指数、全血黏度低切、全血黏度中切、全血黏度高切指标均低于治疗前

且观察组低于对照1组、对照2组

差异均有统计学意义(P<0.05);治疗后

对照1组患者红细胞聚集指数、全血黏度低切、全血黏度中切、全血黏度高切指标均低于对照2组

差异均有统计学意义(P<0.05)。观察组、对照1组、对照2组患者治疗期间不良反应发生率分别为6.12%、4.08%、12.24%

差异无统计学意义(P>0.05)。结论在DN的治疗中

花子地黄汤联合贝那普利治疗能有效缓解患者的临床症状

改善肾功能

调节微循环

疗效确切

且不会增加不良反应

具有较高的安全性。

Abstract

Objective To investigate the effects of huazi dihuang decoction combined with benazepril on the renal function

TCM symptoms and microcirculatory indexes of patients with diabetic nephropathy（DN）. Methods One hundred and forty-seven DN patients admitted to a hospital in Shenyang from August 2018 to August 2020 were selected for the study

and were divided into observation group

control group 1

and control group 2 using a random number table

with 49 cases in each group. Patients in the observation group were treated with huazi dihuang decoction combined with benazepril

patients in control group 1 were treated with huazi dihuang decoction

and patients in control group 2 were treated with benazepril; patients in all three groups were treated continuously for 12 weeks. The clinical efficacy of the three groups was compared; the renal function

TCM symptom scores and blood microcirculation indexes of the three groups were compared before and after treatment; the occurrence of adverse reactions during the treatment was compared between the three groups. Results The total clinical treatment efficacy of patients in the observation group

control group 1 and control group 2 was 93.88%

79.59% and 79.59%

respectively

and that of the observation group was higher than those of control groups 1 and 2

and with statistically significant differences（P<0.05）. Before treatment

there was no statistically significant difference in the levels of urinary microalbumin（m ALB）

blood urea nitrogen（BUN） and serum creatinine（Scr） between the three groups（P>0.05）; after treatment

the levels of m ALB

BUN and Scr in the three groups were lower than those before treatment and lower in the observation group than in control groups 1 and 2

with statistically significant differences（P<0.05）; after treatment

the levels of m ALB

BUN and Scr in control group 1 were lower than those in control group 2

and the differences were statistically significant（P<0.05）. Before treatment

there was no statistically significant difference between the TCM symptom scores of dizziness and tinnitus

palpitation and shortness of breath

tiredness and weakness

night sweating and spontaneous sweating in the three groups（P>0.05）; after treatment

the TCM symptom scores of dizziness and tinnitus

palpitation and shortness of breath

tiredness and weakness

night sweating and spontaneous sweating in the three groups were lower than those before treatment and lower in the observation group than in control groups 1 and 2

with statistically significant differences（P<0.05）; after treatment

the TCM symptom scores of dizziness and tinnitus

palpitation and shortness of breath

tiredness and weakness

night sweating and spontaneous sweating in control group 1 were lower than those in control group 2

and the differences were statistically significant（P<0.05）. Before treatment

there was no statistically significant difference between the erythrocyte aggregation index

total blood viscosity low cut

total blood viscosity medium cut and total blood viscosity high cut indexes of the three groups（P>0.05）; after treatment

the erythrocyte aggregation index

total blood viscosity low cut

total blood viscosity medium cut and total blood viscosity high cut indexes of the three groups were lower than those before treatment and lower in the observation group than in control groups 1 and 2

and with statistically significant differences（P<0.05）; after treatment

the erythrocyte aggregation index

whole blood viscosity low cut

whole blood viscosity medium cut and whole blood viscosity high cut indexes were all lower in control group 1 than in control group 2

and the differences were statistically significant（P<0.05）. The incidence of adverse reactions during treatment in the observation group

control group 1 and control group 2 was 6.12%

4.08% and 12.24%

respectively

and the differences were not statistically significant（P>0.05）.Conclusion In the treatment of DN

huazi dihuang decoction combined with benazepril can effectively relieve the clinical symptoms of patients

improve renal function

regulate blood microcirculation

with evident efficacy and no increase in adverse reactions

thus showing a high safety profile.

关键词

糖尿病肾病花子地黄汤贝那普利肾功能中医证候微循环不良反应

Keywords

Diabetic nephropathyHuazi dihuang decoctionBenazeprilRenal functionTCM symptomsMicrocirculationAdverse reactions

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