Objective To explore the clinical effects of fibrinolytic enzyme combined with compound danshen injection in the treatment of encapsulated tuberculous pleurisy. Methods Eighty cases of patients with encapsulated tuberculous pleurisy treated in a hospital in Nanyang from June 2018 to November 2020 were selected as study subjects and divided into observation and control groups using a random number table

with 40 cases in each group. The patients in the control group were treated with fibrinolytic enzyme injection

and the patients in the observation group were treated with compound danshen injection on the basis of the control group. The clinical efficacy

the disappearance time of pleural effusion

as well as pleural thickness and coagulation functions including prothrombin time（PT）

fibrinogen（FIB） level and thrombin time（TT） before and after the treatment were compared between the 2 groups. Results The total effective rate of treatment for patients in the observation group was 95.00%（38/40）

which was higher than that of 80.00%（32/40） in the control group

and the difference was statistically significant（χ~2=4.114

P=0.043）. The disappearance time of pleural effusion was shorter in the observation group than in the control group

and the difference was statistically significant（t=7.240

P<0.001）. The pleural thickness after treatment was smaller than before treatment in both groups

and it was smaller in the observation group than in the control group

with statistically significant differences（P<0.05）. the FIB level after treatment was lower than before treatment in both groups

and it was lower in the observation group than in the control group

with statistically significant differences（P <0.05）; the differences were not statistically significant（P>0.05） when comparing PT and TT after treatment in the 2 groups. Conclusion Fibrinolytic enzyme combined with compound danshen injection is effective in the treatment of encapsulated tuberculosis pleurisy

as it promotes the absorption of pleural effusion

reduces the thickness of pleura and improves the coagulation function of patients.