Objective To investigate the clinical efficacy of Xieyu Yunpi decoction combined with gemcitabine in the treatment of pancreatic cancer. Methods Sixty-two patients with middle and late-stage pancreatic cancer admitted to a hospital in Huludao from March 2019 to March 2020 were selected for the study and were randomly divided into a Western medicine group and a Chinese and Western medicine group

31 cases each

by the parity of their hospitalization numbers. Patients in the Western medicine group were treated with gemcitabine intravenously on the first and the eighth day of each 3-week course of treatment; patients in the Chinese and Western medicine group were treated with Western medicine（the specific medication method was the same as that of the Western medicine group） combined with oral treatment of Xieyu Yunpi decoction

1 dose/day

and both groups received continual treatment for 6 weeks. The visual analog scale（VAS） scores

coagulation indexes

TCM symptom scores and Karnofsky performance scale（KPS） scores were compared before and after treatment in the 2 groups. Results Before treatment

there was no statistically significant difference between the VAS scores of patients in the 2 groups（P>0.05）; after treatment

the VAS scores of patients in the 2 groups were lower than before treatment and lower in the Chinese and Western medicine group than in the Western medicine group

with statistically significant differences（P<0.05）. Before treatment

there was no statistically significant difference between the D-D and APTT of the 2 groups（P>0.05）; after treatment

the D-D levels of the 2 groups were lower than before treatment

and those of the Chinese and Western medicine treatment group were lower than those of the Western medicine treatment group

with statistically significant differences（P<0.05）; after treatment

the APTT of the both groups was longer than before treatment

and that of the Chinese and Western medicine group was longer than that of the Western medicine group

with statistically significant differences（P <0.05）. Before treatment

there was no statistically significant difference in the scores of upper abdominal or lumbar pain

jaundice

frequent sighing and tiredness between the 2 groups（P>0.05）; after treatment

the scores of upper abdominal or lumbar pain

jaundice

frequent sighing and tiredness in both groups were lower than those before treatment and the lower in the Chinese and Western medicine group than in the Western medicine group

with statistically significant differences（P<0.05）. Before treatment

there was no statistically significant difference between the KPS scores of the two groups（P>0.05）; after treatment

the KPS scores of the two groups were higher than before treatment

and those of the Chinese and Western medicine group was higher than those of the Western medicine group

with statistically significant differences（P<0.05）. Conclusion The combination of Xieyu Yunpi decoction and gemcitabine can effectively improve the pain

coagulation function

TCM syndrome scores and physical condition of patients with pancreatic cancer in the middle and late stages.