Objective To investigate the clinical effect of implementing a combined nursing program（traditional Chinese medicine nursing+cluster nursing） in the treatment of patients with severe acute pancreatitis（SAP） and the effect on patients’ immune function

inflammatory factors

and biochemical indicators of pancreatic injury. Methods Eighty-four patients with SAP who received Chinese and Western medicine treatment in a hospital in Henan from July 2020 to June 2021 were selected as study subjects

and the patients were divided into observation and control groups of 42 cases each using the random number table method. Patients in the control group were given cluster care

and patients in the observation group were given a combined care plan（traditional Chinese medicine care+cluster care）. The immune function indicators [T lymphocyte subsets（CD4

+

CD8

+

）

CD4

+

/CD8

+

]

inflammation indicators [white blood cells（WBC）

C-reactive protein（CRP）

interleukin-6（IL-6）

lipopolysaccharide（LPS）]

and biochemical indicators of pancreatic injury [serum amylase（AMY）

lipase（LIP）] were compared between the 2 groups of patients before and at 2 weeks of intervention. Results Before the intervention

there was no statistically significant difference between the CD4

+

CD8

+

and CD4

+

/CD8

+

levels in the 2 groups（P

>

0.05）; after the intervention

the CD4

+

and CD4

+

/CD8

+

levels in the 2 groups were higher than before the intervention and higher in the observation group than in the control group; the CD8

+

levels in the 2 groups were lower than before the intervention and lower in the observation group than in the control group. All differences were statistically significant（P

<

0.05）. Before the intervention

there was no statistically significant difference between the WBC

CRP

IL-6 and LPS levels in the 2 groups（P

>

0.05）; after the intervention

the WBC

CRP

IL-6 and LPS levels in the 2 groups were lower than before the intervention and lower in the observation group than in the control group

with statistically significant differences（P

<

0.05）. Before the intervention

there was no statistically significant difference between the AMY and LIP levels in the 2 groups（P

>

0.05）. After the intervention

the AMY and LIP levels in the 2 groups were lower than before the intervention and lower in the observation group than in the control group

with statistically significant differences（P

<

0.05）. Conclusion The implementation of combined nursing scheme（traditional Chinese medicine nursing+cluster nursing） in the course of Chinese and Western medicine therapy（Chai Qin Cheng Qi Decoction+Ustatin） has significant clinical effects. It can effectively improve the immune function of patients

control the inflammatory response and reduce pancreatic injury

and is worthy of clinical promotion and application.