Objective To explore the effect of systematic nursing in continuous renal replacement therapy（CRRT） for the treatment of severe acute pancreatitis. Methods One hundred and six patients with severe acute pancreatitis admitted to a hospital in Luohe from December 2018 to February 2021 were selected for the study

and were divided into a systematic group（n=53） and a control group（n=53） according to the time of admission. Patients in the control group were given conventional care

and patients in the systematic group were given systematic care on the basis of the control group; both groups received continuous care until discharge. The length of stay in the intensive care unit（ICU） and the incidence of complications were compared between the two groups

and the scores of the Acute Physical And Chronic Health Evaluation II（APACHE-Ⅱ）

self-rating anxiety scale（SAS） and self-rating depression scale（SDS） were compared between the two groups before and after care. Results Before care

there was no statistically significant difference between the APACHE-Ⅱ scores of the 2 groups of patients（P>0.05）; after care

the APACHE-Ⅱ scores of the 2 groups of patients were lower than before care and lower in the systematic group than in the control group

with statistically significant differences（P<0.05）. Before care

there was no statistically significant difference between the SAS and SDS scores of patients in the 2 groups（P>0.05）; after care

the SAS and SDS scores of patients in the 2 groups were lower than before care and lower in the systematic group than in the control group

with statistically significant differences（P<0.05）. The ICU stay of patients in the systematic group was 15.32±3.76 d

shorter than that of the control group（19.69±3.87 d）

and the difference was statistically significant（t=5.896

P<0.001）. The complication rate of patients in the systematic group was 3.77%

which was lower than that of 16.98% in the control group

with a statistically significant difference（P<0.05）. Conclusion Systematic care in patients with severe acute pancreatitis undergoing CRRT can effectively improve patients’ negative emotions

shorten the ICU stay

accelerate recovery

and have a lower risk of complications. It is worth promoting the use in clinical practice.