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大连市中心医院神经电生理科
纸质出版日期:2021,
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姜家奇, 殷宏宇, 王晓虹. 单侧颞叶癫痫患者脑电图网络变化与执行功能的关系[J]. 保健医学研究与实践, 2021,18(5):84-88.
Jiang Jiaqi, Yin Hongyu, Wang Xiaohong. Relationship between EEG network changes and executive function in patients with unilateral temporal lobe epilepsy[J]. Health Medicine Research and Practice, 2021,18(5):84-88.
目的探讨单侧颞叶癫痫(TLE)患者脑电图网络变化与执行功能的关系。方法选取2017年3月—2020年3月辽宁省某医院癫痫门诊收治的87例单侧TLE患者
根据病灶位置分为左侧TLE(L-TLE)组(n=43)和右侧TLE(R-TLE)组(n=44)
选取同期到医院体检的健康志愿者作为对照组(n=28)。受试对象统一进行功能磁共振成像(fMRI)检查和执行功能测验。比较3组对象一般资料、默认模式网络(DMN)静息态功能连接差异脑区、执行功能测验结果。分析TLE患者经Fisher-z转换的差异脑区功能连接值(zFC)与执行网络效率值的相关性。结果 L-TLE组DMN静息态功能连接下降脑区为右额上回内侧、双侧额中回、左侧枕中回、左侧距状裂皮质
增强脑区为左侧颞中回、左额上回内侧;R-TLE组DMN静息态功能连接下降脑区为右侧前扣带回、左侧中间扣带回、右侧楔前叶
增强脑区为左侧楔前叶、右侧顶下小叶、左侧顶下小叶。L-TLE组和R-TLE组朝向一致目标反应时间、双朝向目标反应时间及执行网络效率值均大于对照组
差异均有统计学意义(P<0.05);R-TLE组执行网络效率值小于L-TLE组
差异有统计学意义(P<0.05)。L-TLE组左额上回内侧zFC值与执行网络效率值呈正相关(r=0.624
P=0.023)。结论单侧TLE患者存在DMN静息态功能连接异常和执行功能障碍
L-TLE患者较R-TLE患者DMN静息态功能连接异常脑区分布更广、执行功能障碍更严重
且患者脑电图网络变化与执行功能障碍有关。
Objective To investigate the relationship between the changes of EEG network and executive function in patients with unilateral temporal lobe epilepsy(TLE). Methods A total of 87 patients with unilateral TLE treated in the epilepsy clinic of a hospital in Liaoning Province from March 2017 to March 2020 were divided into left L-TLE group(n=43) and R-TLE group(n=44) according to the location of the lesions. Healthy volunteers who went to the hospital for physical examination in the same period were selected as control group(n=28). The subjects were examined by functional magnetic resonance imaging(fMRI) and executive function test. The general data
the resting state functional connection differences of the default mode network(DMN) and the results of executive function test of the three groups were compared. The correlation between the functional connection value(z FC) of differential brain regions converted by Fisher-z and the efficiency of executive network in patients with TLE was analyzed. Results In L-TLE group
the descending brain regions of DMN resting functional connections were right superior frontal gyrus
bilateral middle frontal gyrus
left middle occipital gyrus and left talar cleft cortex. The enhanced brain regions were left middle temporal gyrus and left superior frontal gyrus. In R-TLE group
the descending brain regions of DMN resting functional connections were right anterior cingulate gyrus
left middle cingulate gyrus and right precuneus. The enhanced brain regions were left precuneus
right inferior parietal lobule and left inferior parietal lobule. The response time towards the same orientation
the reaction time to double orientation and the efficiency of execution network in L-TLE group and R-TLE group were significantly higher than those in control group(P<0.05). The network efficiency in R-TLE group was significantly lower than that in L-TLE group(P<0.05). In L-TLE group
the z FC value of left superior frontal gyrus was positively correlated with the efficiency of executive network(r=0.624
P=0.023). Conclusion Unilateral TLE patients have abnormal DMN resting state functional connections and abnormal executive dysfunction. The distribution of abnormal DMN resting state functional connections in L-TLE patients is wider than that in R-TLE patients
the executive dysfunction is more serious
and the changes of EEG network are related to executive dysfunction.
颞叶癫痫功能磁共振成像默认模式网络静息态功能连接执行功能
Temporal lobe epilepsyFunctional magnetic resonance imagingDefault mode networkResting state functional connectionExecutive function
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