硒酵母片联合左甲状腺素治疗对妊娠期甲状腺功能减退症患者FT<sub>3</sub>、FT<sub>4</sub>以及TSH水平的影响

马艳庆; 张晓娟

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硒酵母片联合左甲状腺素治疗对妊娠期甲状腺功能减退症患者FT₃、FT₄以及TSH水平的影响

临床医学 | 更新时间：2022-11-04

- 硒酵母片联合左甲状腺素治疗对妊娠期甲状腺功能减退症患者FT₃、FT₄以及TSH水平的影响
- Effect of selenium yeast tablets and levothyroxine combination treatment on FT₃, FT₄ and TSH levels in patients with hypothyroidism during pregnancy
- 保健医学研究与实践 2021年18卷第5期页码：80-83
- 作者机构：
  
  平煤神马医疗集团总医院内分泌科
- 作者简介：
- 基金信息：
- DOI：
  中图分类号： R714.256
- 纸质出版日期：2021，
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马艳庆, 张晓娟. 硒酵母片联合左甲状腺素治疗对妊娠期甲状腺功能减退症患者FT₃、FT₄以及TSH水平的影响[J]. 保健医学研究与实践, 2021,18(5):80-83.

Ma Yanqing, Zhang Xiaojuan. Effect of selenium yeast tablets and levothyroxine combination treatment on FT₃, FT₄ and TSH levels in patients with hypothyroidism during pregnancy[J]. Health Medicine Research and Practice, 2021,18(5):80-83.
马艳庆, 张晓娟. 硒酵母片联合左甲状腺素治疗对妊娠期甲状腺功能减退症患者FT₃、FT₄以及TSH水平的影响[J]. 保健医学研究与实践, 2021,18(5):80-83. DOI：

Ma Yanqing, Zhang Xiaojuan. Effect of selenium yeast tablets and levothyroxine combination treatment on FT₃, FT₄ and TSH levels in patients with hypothyroidism during pregnancy[J]. Health Medicine Research and Practice, 2021,18(5):80-83. DOI：

摘要

目的探讨硒酵母片联合左甲状腺素治疗对妊娠期甲状腺功能减退症患者游离甲状腺原氨酸（FT

）

促甲状腺素（TSH）以及游离四碘甲状腺原氨酸（FT

）水平的影响。方法选取2019年10月—2020年10月河南省某医院收治的116例妊娠期甲状腺功能减退症患者为研究对象

采用随机数字表法将患者分为对照组（n=58）与研究组（n=58）。对照组患者给予左甲状腺素治疗

研究组患者给予硒酵母片联合左甲状腺素治疗

2组患者均持续治疗至妊娠期结束。比较2组患者临床疗效、妊娠不良结局、不良反应发生情况及患者治疗前后血清FT

、TSH以及FT

水平。结果对照组患者治疗总有效例数为44例

治疗总有效率为75.9%;研究组患者治疗总有效例数为55例

治疗总有效率为94.8%。研究组患者治疗总有效率明显高于对照组

差异有统计学意义（P

0.05）。对照组患者妊娠不良结局例数为11例

妊娠不良结局发生率为19.0%;研究组患者妊娠不良结局例数为2例

妊娠不良结局发生率为3.4%。研究组患者妊娠不良结局发生率明显低于对照组

差异有统计学意义（P

0.05）。对照组患者发生不良反应例数为11例（皮肤瘙痒3例、恶心呕吐8例）

不良反应发生率为19.0%。研究组患者发生不良反应例数为3例（皮肤瘙痒1例、恶心呕吐2例）

不良反应发生率为5.1%。研究组患者不良反应发生率明显低于对照组

差异有统计学意义（P

0.05）。治疗前

2组患者血清FT

、FT

以及TSH水平比较

差异无统计学意义（P

0.05）。治疗后

2组患者血清FT

、FT

水平高于治疗前

且研究组患者明显高于对照组

差异均有统计学意义（P

0.05）;2组患者血清TSH水平明显低于治疗前

且研究组患者明显低于对照组

差异有统计学意义（P

0.05）。结论硒酵母片联合左甲状腺素治疗可有效改善妊娠期甲状腺功能减退症患者血清FT

、FT

以及TSH水平

降低患者用药后不良反应及妊娠不良结局发生率

疗效显著

可推广应用。

Abstract

Objective To investigate the effects of selenium yeast tablets combined with levothyroxine on free triiodothyronine（FT

）

thyroid stimulating hormone（TSH） and free tetraiodothyronine（FT

） levels in patients with hypothyroidism during pregnancy. Methods One hundred and sixteen patients with hypothyroidism during pregnancy admitted to a hospital in Henan Province from October 2019 to October 2020 were selected for the study

and the patients were divided into a control group（n=58） and a study group（n=58） using a random number table. Patients in the control group were treated with levothyroxine

while patients in the study group were treated with selenium yeast tablets combined with levothyroxine

and both groups received continuous treatment until the end of pregnancy. The clinical efficacy of patients in the two groups was compared; the adverse pregnancy outcomes and the occurrence of adverse reactions in the two groups were compared; the serum FT

TSH and FT

levels of patients in the two groups before and after treatment were compared. Results The total number of effective cases in the control group was 44

and the total effective rate was 75.9%; the total number of effective cases in the study group was 55

and the total effective rate was 94.8%. The total effective rate of treatment in the study group was significantly higher than that in the control group（P

0.05）. The number of patients in the control group with adverse pregnancy outcome was 11

and the incidence of adverse pregnancy outcome was 19.0%; the number of patients in the study group with adverse pregnancy outcome was 2

and the incidence of adverse pregnancy outcome was 3.4%. The incidence of adverse pregnancy outcomes in the study group was significantly lower than that in the control group（P

0.05）. The number of adverse reactions in the control group was 11（3 cases of pruritus and 8 cases of vomiting）

and the incidence of adverse reactions was 19.0%. The number of adverse reactions in the study group was 3（1 case of skin itching and 2 cases of vomiting）

and the incidence of adverse reactions was 5.1%. The incidence of adverse reactions in patients in the study group was significantly lower than that in the control group（P

0.05）. Before treatment

there was no statistically significant difference between the serum FT

and TSH levels of patients in the 2 groups（P

0.05）. After treatment

the serum FT

and FT

levels of patients in the 2 groups were higher than those before treatment

and those of the patients in the study group were significantly higher than those in the control group（P

0.05）; the serum TSH levels of patients in the 2 groups were significantly lower than those before treatment

and those of patients in the study group were significantly lower than those in the control group（P

0.05）. Conclusion Selenium yeast tablets combined with levothyroxine can effectively improve serum FT

and TSH levels in patients with hypothyroidism during pregnancy and reduce the incidence of adverse reactions and adverse pregnancy outcomes in patients after medication. The efficacy of the therapy is significant

and it can be promoted.

关键词

硒酵母片左甲状腺素妊娠期甲状腺功能减退症FT3FT4TSH

Keywords

Selenium yeast tabletsLevothyroxinePregnancyHypothyroidismFT3FT4TSH

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Effect of selenium yeast tablets and levothyroxine combination treatment on FT3, FT4 and TSH levels in patients with hypothyroidism during pregnancy

DOI：

摘要

Abstract

关键词

Keywords

references

硒酵母片联合左甲状腺素治疗对妊娠期甲状腺功能减退症患者FT₃、FT₄以及TSH水平的影响

Effect of selenium yeast tablets and levothyroxine combination treatment on FT₃, FT₄ and TSH levels in patients with hypothyroidism during pregnancy