To investigate the impact of maternal separation（MS）on neurodevelopment

to figure out suitable nursing methods for children with MS

and to provide a theoretical basis for promoting the wide application of Kangaroo Mother Care（KMC）.Literature was reviewed to summarize the research advances in the impact of MS on animal neurodevelopment and behavior and nursing intervention.MS causes anxiety-depression-like

addictive

and obedience behavior in offspring.Moreover

it leads to apoptosis of astrocytes and changes in tissue composition in the hippocampus of rat brain

which results in weaker learning and memory abilities as well as the corresponding nervous system diseases during adulthood of MS rats.However

further studies are needed for the harmful effects of MS on the central nervous system and their mechanisms.KMC is considered to be able to block the adverse effects of MS and provide short-term and long-term benefits to neurodevelopment.However

more types of intuitive research are still needed.More attention should be paid to the long-term effects of MS on newborns.KMC should be provided for mothers and infants to reduce the harmful effects of MS and promote neurodevelopment in children.