Objective To explore the effects of Seretide combined with tiotropium bromide onpulmonary function

immune function and airway resistance in patients with chronic obstructive pulmonary disease（COPD）complicated with bronchial asthma.Methods A total of 102 patients with COPD and bronchial asthma who were treated in a hospital in Liaoning from January 2017 to December 2018 were selected for the study and were divided into study group and control group according to the random number table method

with 51 cases in each group.Control group was treated with tiotropium bromide

and study group was given Seretide combined with tiotropium bromide.Pulmonary function[forced expiratory volume in 1 st second（FEV1）

peak expiratory flow rate（PEF）

forced vital capacity（FVC）]

immune function[T lymphocyte subset CD4

+

CD8

+

CD4

+

/CD8

+

natural killer cells（NK cells）]and airway resistance[total airway impedance（Z5）

total airway viscous resistance（R5）

proximal airway viscous resistance（R20）]

were compared between the two groups before treatment and 2 weeks of treatment.Quality of life[Short-form Quality of Life Scale（SF-36）]was compared between the two groupsbefore treatment and 3 months of treatment.Results After 2 weeks and 3 months of treatment

the FEV1

PEF

FVC

CD4

+

CD4

+

/CD8

+

NK cells and levels of MCS and PCS of SF-36 in the two groups were significantly higher than those before treatment

and the indexes in study group were significantly larger than those in control group at the same time period（all P

<

0.05）.The levels of CD8

+

Z5

R5 and R20 in the two groups were significantly lower than those before treatment

and the indexes in study group were significantly smaller than those in control group at the same time period（all P

<

0.05）.Conclusion Seretide combined with tiotropium bromide has good effects in the treatment of COPD with bronchial asthma

and it can effectively improve pulmonary function and immune function and reduce airway resistance.