Objective To investigate the effect of clopidogrel and aspirin combined with sodium butyphthalide injection on neurological function and quality of life in patients with progressive cerebral infarction.Methods From January 2016 to December 2018

196 patients with progressive cerebral infarction in a hospital in Henan province were selected as the study subjects.Patients in the control group were treated with clopidogrel

aspirin

and patients in the study group were treated with sodium butyphthalide on the basis of treatment in the control group.At 2 weeks of treatment

the therapeutic effect of 2 groups of patients was compared The US National Hospital Stroke Scale（NIHSS）scores were compared between 2 groups of patients before treatment and at 1 and 2 weeks of treatment.The adverse reaction rates were compared between 2 groups of patients at 2 weeks of treatment.Results The total effective rate of treatment in the study group was 94.90%

which was higher than 80.61%in the control group

and the difference was statistically significant（P<0.05）.The NIHSS scores in the study group were（10.48±1.91）and（4.85±0.98）

lower than the control group（13.64±2.78）and（6.97±1.47）

the difference was statistically significant（P<0.05）.The total incidence of adverse reactions in the study group and the control group was 7.14%and 5.10%

respectively

and the difference was not statistically significant（P>0.05）.The scores of BI and WHOQOL-100 in the study group were（89.28±6.31）and（88.26±7.84）

respectively

higher than those in the control group（74.29±5.18）and（75.35±5.07）

the difference was statistically significant（P<0.05）.Conclusion Clopidogrel

sodium butyphthalide and aspirin

is effective in the treatment of progressive cerebral infarction.It can improve the nerve function

the daily life ability and quality of life of the patients.