Objective To investigate the expression of ribosome binding protein 1（RRBP1）in colorectal cancer（CRC）tissues and its clinical significance.Methods A total of 184 CRC tissues and adjacent normal tissue specimens from CRC patients treated in a hospital in Sichuan province from July 2016 to July 2018 were collected.RRBP1 expression was detected by immunohistochemistry

and the relationship between RRBP1 expression and clinical pathological parameters and prognosis of patients was analyzed.Results The positive expression rate of RRBP1 in colorectal cancer was 79.35%（146/184）

which was significantly higher than 19.02%（35/184）of normal tissue adjacent to the cancer（P<0.05）.There was no significant difference in the positive expression rate of RRBP1 among patients of different ages

genders

and tumor sites（P>0.05）;there was a statistically significant difference in the positive expression rate of RRBP1 among patients with different tumor sizes

TNM stages

differentiation

and lymph node metastasis（P<0.05）.Cox regression analysis showed that positive expression of RRBP1

TNM stage III/IV

poor differentiation

and lymph node metastasis were risk factors for the prognosis of CRC patients（P<0.05）.Conclusion RRBP1 is highly expressed in colorectal cancer tissues;positive expression of RRBP1 is a prognostic risk factor for patients with CRC;RRBP1 as a molecular marker can provide a reference for the diagnosis and prognosis of colorectal cancer

and is worthy of clinical reference.