Objective To observe the effect of continuous drainage of lumbar cistern combined with fasudil in preventing cerebral vasospasm after subarachnoid hemorrhage.Methods Ninety-three patients with subarachnoid hemorrhage caused by ruptured intracranial aneurysm treated in a hospital in Liaoning from January 2018 to April2019 were enrolled as the research subjects

and subsequently divided into a control group（46 cases）and an observation group（47 cases）by the random number table method.Both groups were treated with intracranial aneurysm clipping

routine symptomatic supportive treatment and continuous lumbar cistern drainage

and the observation group was treated with fasudil in addition.The incidence of cerebral vasospasm and cerebrospinal fluid pressure of the two groups

cerebrospinal fluid red blood cell count and brain CT perfusion imaging related parameters of the two groups at different time points

as well as serum matrix metalloproteinase（MMP-9）and S-100 calcium binding protein（S-100 B）levels and National Institutes of Health Stroke Scale（NIHSS）scores of both groups before and after treatment were compared.Results The cerebrospinal fluid pressure and cerebrospinal fluid red blood cell count of the two groups decreased gradually with the increase of treatment time.There was a statistically significant difference in cerebrospinal fluid pressure and cerebrospinal fluid red blood cell count at different time points in each group（P<0.05）

but the difference between the two groups at different time points was insignificant（P>0.05）.There was no significant difference in cerebral blood volume（CBV）or cerebral blood flow（CBF）on the 3 rd day of treatment（P>0.05）.CBV and CBF of the treatment group on the 7 th day and the 14 th day of treatment were all lower than those of the control group（P<0.05）.Before treatment

there was no significant difference in serum MMP-9 and S-100 Blevels between the two groups（P>0.05）;the levels of serum MMP-9 and S-100 Bin both groups decreased after treatment

and those of the observation group were significantly lower than those of the control group（P<0.05）.The incidence of cerebral vasospasm in the observation group was lower than that in the control group（P<0.05）.Before treatment

there was no significant difference in NIHSS scores between the two groups（P>0.05）;the NIHSS scores of both groups decreased after treatment

and those of the observation group were significantly lower than those of the control group（P<0.05）.Conclusion On the basis of continuous lumbar cistern drainage

the additional use of fasudil can effectively prevent cerebral vasospasm after subarachnoid hemorrhage

reduce neurological impairment

and improve patient′s prognosis.