Objective To study the dynamic variation of hepatocyte growth factor （HGF） in serums of acute heart stem （AMI） patients.Method HGF of 22 AMI patients was measured with radio immunoassay 12 h

24 h

48 h

96 h and 7 d after the attack

and 20 healthy subjects constituted the control group.Results 12 h

24 h

48 h

96 h and 7 d after the attack

HGF in plasma of AMI patients was much higher than that in the control group （P<0.01）

and evident dynamic variation was observed.Level of HGF 7 d after the attack was higher than that 12 h

24 h

48 h and 96 h after it （P<0.01）;HGF of AMI patients was positively correlated with the worsening of heart function （r=0.564

P<0.01）.Conclusion The growth of HGF in plasma of AMI patients and the worsening of heart function contributes to the growth of HGF.