Objective To study the clinical effects of L-carnionc and Shuxuetong on chronic renal failure.Method 98 patients of light or moderate chronic renal failure with non-dialysis therapy were randomly divided into three groups

i.e.L-carnionc group

treated only with L-carnionc

and Shuxuetong group

with Shuxuetong.The third group combined both therapies.The index of renal function were evaluated after 4-week treatment.Results After 4-week treatment there were decreases of the Scr、Bun、hs-CRP、mAlb in 3 groups（P<0.05 or P<0.01）and there were no significant difference in UP before and after treatment in 3 groups.Conclusion L-carnionc and Shuxue tong are effective to the chronic renal failure.