Objective To explore the safety and efficacy of minimally invasive curative-intent resection for gallbladder carcinoma. Methods The clinicopathological data of 126 patients who underwent curative-intent resection for gallbladder carcinoma in the Department of Hepatobiliary Surgery of First Affiliated Hospital of Xi’an Jiaotong University from January 2022 to August 2023 was retrospectively analyzed. There were 38 males patients（30.2%）and 88 females patients（69.8%）；age 40 to 88（63.3 ± 8.8）years old； and there were 92 cases in the open surgery group（73.0%）and 34 cases（27.0%）in the minimally invasive surgery group，of which included 5 cases who underwent robotic-assisted surgery. By comparing the clinicopathological data differences between the open surgery group and the minimally invasive surgery group before and after propensity score matching（1:1 matching），we analyzed the operative time，intraoperative bleeding，intraoperative blood transfusion，number of lymph node dissection，postoperative recovery，occurrence of complications，length of hospital stays，and hospital costs between the two groups. Results There was no statistically significant difference in baseline data between the open surgery group and the minimally invasive surgery group after propensity score matching（P > 0.05）. The results showed that the minimally invasive surgery group had a longer operation time than that in the open surgery group （314.3 ± 116.5 min vs. 234.3 ± 65.2 min，P = 0.001），but there were no statistical differences between the two groups in the intraoperative bleeding，intraoperative transfusion of erythrocytes，transfusion of plasma，whether the hepatic hilum was blocked，number of hepatic hilum blocks，duration of hepatic hilum block，number of lymph node dissection，number of positive lymph nodes，and surgical margins（P > 0.05）；there was no statistically significant difference between the two groups in the occurrence of postoperative complications and those with C-D grading of complications ≥ grade III（P > 0.05）；the time for the first postoperative meal and the time for removing the drainage tube in the minimally invasive group were shorter than those in the open surgery group（P < 0.05）；the postoperative hospital stay in the minimally invasive surgery group was shorter than that of the open surgery group（7.0 d vs. 8.0 d，P = 0.014）， and there was no statistically significant difference in the total length of hospital stays and the total hospital costs（P > 0.05）. Conclu⁃ sion Minimally invasive curative-intent resection of gallbladder carcinoma showed good surgical safety and efficacy，which could help patients recover quickly，and had certain clinical application value.