Objective To observe the effect of scalp nerve block combined with general anesthesia on the quality of early postoperative recovery in patients undergoing neurosurgery. Methods A total of 93 patients who underwent scheduled neurosurgery at Yaan people’s Hospital from July 2020 to May 2022 were divided into a control group （45 cases） and an observation group （48 cases）. The control group received general anesthesia，while the observation group received scalp nerve block combined with general anesthesia under ultrasound guidance. VSA score at 4，8，12 and 24 hours after the operation were recorded. Intraoperative analgesic drugs usage，length of hospital stay，incidence of agitation during the awakening period，and incidence of postoperative nausea and vomiting were observed and recorded in both groups. The Chinese version of the Quality of Recovery Scale （QoR） was used to assess the preoperative and postoperative （at 3 and 7 days） recovery quality in both groups. Results The observation group had lower VSA scores at 4，8，12，and 24 hours postoperatively compared to the control group （P < 0.05）. The intraoperative remifentanil dosage was also lower in the observation group （P < 0.05）. The QoR scores at 3 days postoperatively were higher in the observation group （P < 0.05）. The observation group had a shorter hospital stay （P < 0.05） and lower incidence of agitation during the awakening period，as well as postoperative nausea and vomiting （P < 0.05），compared to the control group. Conclusion Scalp nerve block combined with general anesthesia was effective for analgesia in patients undergoing neurosurgery and facilitated early postoperative recovery.